The appearance of hypersensitivity reactions requires cessation of therapy with probenecid and colchicine.

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Gastrointestinal disorders are the most common adverse reactions with colchicine. They are often the first signs of toxicity and may indicate that the colchicine dose needs to be reduced or therapy stopped. These include diarrhea.nausea.vomiting.and abdominal pain.

Fatal overdoses.both accidental and intentional.have been reported in adults and children who have ingested colchicine [See OVERDOSE ]. Colchicine capsules should be kept out of the reach of children.

Published reports on the pharmacokinetics of intravenous colchicine in patients with severe chronic liver disease.as well as those with alcoholic or primary biliary cirrhosis.and normal renal function suggest wide inter-patient variability. In some subjects with mild to moderate cirrhosis.the clearance of colchicine is significantly reduced and plasma half-life prolonged compared to healthy subjects. In subjects with primary biliary cirrhosis.no consistent trends were noted [See Hepatic Impairment ]. No pharmacokinetic data are available for patients with severe hepatic impairment(Child-Pugh C).

Heart Problems. People who take ULORIC can have serious heart problems including heart attacks.strokes and heart-related deaths. It is not known that ULORIC caused these problems. Call your healthcare provider right away or get emergency medical help if you have any of the following symptoms. chest pain.shortness of breath.dizziness.numbness or weakness on one side of your body.trouble talking or headache.

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do not take this medicine with any of the following medications -alfuzosin -certain medicines for anxiety or sleep like alprazolam, midazolam, triazolam -certain medicines for blood pressure like felodipine, nisoldipine, eplerenone -certain medicines for cancer like irinotecan, ibrutinib -certain medicines for cholesterol like cerivastatin, lovastatin, simvastatin, lomitapide -certain medicines for irregular heart rate like disopyramide, dofetilide, dronedarone, quinidine -cisapride -colchicine -conivaptan -ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine -lurasidone -methadone -nevirapine -other medicines that prolong the qt interval cause an abnormal heart rhythm -pimozide -ranolazine -red yeast rice -sirolimus -thioridazine -tolvaptan -ziprasidone this medicine may also interact with the following medications -alcohol or any product that contains alcohol -aliskiren -amlodipine -antacids -antiviral medicines for hiv oraids -aprepitant -atorvastatin -bosentan -buprenorphine -certain medicine for bladder problems like fesoterodine, solifenacin, tolterodine -certain medicines for cancer like bortezomib, busulfan, dasatinib, docetaxel, erlotinib, imatinib, ixabepilone, lapatinib, nilotinib, paclitaxel, trimetrexate, vinca alkaloids -certain medicines for depression, anxiety, or psychotic disturbances like aripiprazole, buspirone, haloperidol, quetiapine, risperidone -certain medicines for erectile dysfunction like vardenafil, sildenafil, tadalafil -certain medicines for pain like alfentanil, fentanyl, oxycodone, sufentanil -certain medicines for stomach problems like cimetidine, famotidine, omeprazole, lansoprazole -certain medicines that treat or prevent blood clots like dabigatran, rivaroxaban, warfarin -certain medicines for seizures like carbamazepine, phenytoin -certain medicines for tuberculosis like isoniazid, inh, rifabutin, rifampin, rifapentine -cilostazol -cinacalcet -cyclosporine -digoxin -eletriptan -isradipine -nadolol -nifedipine -other medicines for fungal infections -praziquantel -ramelteon -repaglinide -salmeterol -saxagliptin -steroid medicines like budesonide, ciclesonide, dexamethasone, methylprednisolone -tacrolimus -tamsulosin -telithromycin -verapamil.

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